3/29/2021 0 Comments Acetaminophen Davis Pdf
Uses: -For the management of mild to moderate pain and for the management of moderate to severe pain when used with adjunctive opioid analgesics.Severe liver damage may occur if: -Adult takes more than maximum daily dose in 24 hours -Child takes more than 5 doses in 24 hours -More than 3 alcoholic drinks are consumed per day while using this product.
Suspected Overdose: -If an overdose is suspected, obtain a serum drug level as soon as possible, but no sooner than 4 hours after oral ingestion. Liver function studies should be obtained and repeated at 24-hour intervals. The antidote, N-acetylcysteine (NAC) should be administered as soon as possible according to NAC protocols. In particular, be careful to ensure that - the dose in milligrams (mg) and milliliters (mL) is not confused; - the dosing is based on weight for patients under 50 kg; - infusion pumps are properly programmed; -the total daily dose of acetaminophen from all sources does not exceed maximum daily limits. US BOXED WARNING: HEPATOTOXICITY: This drug has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed the maximum daily limits, and often involve more than 1 acetaminophen-containing product. Severe liver damage may occur if: -More than maximum daily dose is taken in 24 hours -This product is taken with other drugs containing acetaminophen -Three or more alcoholic drinks are consumer every day while using this product. US OVER THE COUNTER LABELING: Adults and children under 12 years of age: This product contains acetaminophen. Severe liver damage may occur if: -Adult takes more than maximum daily dose in 24 hours -Child takes more than 5 doses in 24 hours -This product is taken with other drugs containing acetaminophen -Persons consume 3 or more alcoholic drinks per day while using this product. Safety and efficacy for the treatment of acute pain have not been established in patients younger than 2 years. Chewable tablets: -Chew tablets before swallowing Extended-release: -Swallow whole; do not crush, chew, split, or dissolve Oral disintegrating tablets: -Allow to dissolve in mouth or chew before swallowing Oral suspension: -Shake well before using -Use enclosed measuring device to measure dose Parenteral: -Infuse IV over 15 minutes; ensure infusion pumps are properly programmed -Monitor end of infusion in order to prevent the possibility of an air embolism, especially in cases where this is the primary infusion. Suppositories: For rectal use only -Remove wrapper -Carefully insert suppository well up into the rectum Reconstitutionpreparation techniques: -For IV doses of 1000 mg: May administer without further dilution; may administer by inserting a vented IV set through the septum of the vial. For doses less than 1000 mg: Withdraw the appropriate dose from the vial and place in a separate empty, sterile container (e.g., glass bottle, plastic IV container, or syringe) for IV infusion. Administer within 6 hours of penetrating the vacuum seal of the glass vial. Do not use if particulate matter or discoloration is observed. Do not add other medications to the acetaminophen solution. Acetaminophen Davis How To Givetake ThisIV compatibility: -Diazepam and chlorpromazine hydrochloride are physically incompatible Storage requirements: -IV: Single use only; store at 20C to 25C (68F to 77F); do not refrigerate or freeze General: -Drug-induced hepatotoxicity is preventable; all patients and caregivers need to be educated on how to givetake this drug safely and what to do if more than the recommended dose is consumed. Use of more than 1 acetaminophen-containing product at one time should be discouraged. Hypersensitivity reactions and serious rashes have been reported. Monitoring: -Monitor for nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in upper right part of the stomach, yellow of the skin or eyes, andor flu-like symptoms as this may be an indication of overdose. Monitor for skin reactions Patient advice: -Patients should be advised to follow package directions for over the counter acetaminophen products including observing the maximum single dose and maximum daily dose limits. Patients should be discouraged from using multiple acetaminophen containing products concurrently. Patients should be advised that severe liver damage may occur if more than the recommended amount of this drug is taken; patients should seek medical help promptly if they suspect they have taken too much of this drug or if they experience nausea, vomiting, loss of appetite, or yellowing of the skin or eyes. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |